 This review evaluates the existing evidence for non-pharmacologic modalities in treatment of hydradonitis suprativa, HS, including weight loss, vitamin B12, vitamin D and zinc supplementation, and dietary avoidance of bras yeast. However, limitations such as small study size and lack of randomized control trials limit the strength of evidence for these therapies in HS. Future large-scale investigations are needed to better establish efficacy in dacing regimens for non-pharmacologic treatments in HS. This article was authored by Alexei J. Hendricks, Penelope A. Hurt, Sahil Sikon, and others.