 Abstract neuroticism is a heritable trait composed of several distinct traits, each conferring varying degrees of protection or risk, to once overall health. mitochondrial DNA was used to examine these traits in over 269,500 people, showing that mitochondrial haplogroups account far up to 0.07% of the variation in neuroticism, while also identifying five specific haplogroup markers associated with neuroticism, along with 15 markers associated with anxiety, tension and worried vulnerability. Additionally, within haplogroup genome-wide association studies revealed specific autosomal effects on worried vulnerability in certain haplogroups, which differed from those seen when assessing autosomal effects across all haplogroups. Furthermore, interactions were observed between chromosome 9 regions and mitochondrial haplogroups, suggesting that the mitochondrial genome may contribute to neuroticism and its link to overall health. This article was authored by Charlie Shear, Sarah J. Pickett, David C. M. Lywald and others. We are article.tv, links in the description below.