 This research paper explores the effects of mechanical force on breast cancer cells. It found that mechanical force can affect the behaviour of breast cancer cells by either promoting or suppressing their growth. Specifically, it was discovered that a certain level of force can promote the growth of stem-like cancer cells while too much force can cause them to enter a quiescent state. Furthermore, the researchers also developed an ECM signature based on the fibrinogen-fibronectin-vitronectin-galastin axis that can accurately predict patient prognosis in breast cancer. This discovery has important implications for understanding how mechanical force influences the behaviour of breast cancer cells and may lead to new treatments for breast cancer. This article was authored by Seung Lee, Choe Choe, Xiao Han Liu, and others.