 Okay, good morning everyone. My name is Patricia Kieran. I'm from Chemical Engineering in UCD and on behalf of our work package leaders here this morning and the remainder of our team and institutions around the country, I'm delighted to welcome you to update you on our progress towards supporting Irish, supporting and preparing Irish engineering graduates for advancing global manufacturing competitiveness. Specifically in this case with regard to design simulation for the process I mean pharma and biopharma applications. Just to remind you our objective at the start of this project was to develop a strategy and the resources required to support this strategy to allow us to embed simulation tools, discipline-specific simulation tools into chemical engineering and related curricula for the achievement of professionally relevant skills in our graduates digital literacy related skills, underpinning very specific chemical engineering principles and in the context of biopharma and pharma applications which are central to the pharma and biopharma industry which is a very robust and growing industry in Ireland and globally. Because these are digitally based simulation tools they're key to enhancing digital literacy in our graduates. As befits a project which is focusing on the chemical engineering discipline all of the chemical engineering program the higher education institutions offering chemical engineering programs in the country are involved. UCD, CIT, UCC and the University of Limerick. We're also joined by partner institutions offering cognate disciplines specifically related to the biopharma industry and biosciences. Because we're focusing on developing multimedia rich resources we're relying on and we're delighted to be joined by Cork Institute of Technology leading the multi technology enhanced learning elements of it and we have teaching and learning support specifically from UCD and from DCU. A very important, oh in this team we've had new members who have joined us since I last met with you in November, chemical engineering, academics in UCD and in CIT and also a new staff member from DIT, Dr Dave Doran who is now leading the work package on process control. Because this project is very much focused towards graduates moving from higher education institutions into the workplace it's again appropriate that we would have a very diverse range of external partners and we are relying very heavily on these non funded external partners. The National Institute for Bioprocessing Research and Training. Scale up systems an Irish owned and Irish based company who produced DynaChem which is an industry standard simulation tool for the pharma and biopharma industry. APC which is a process development, optimization and scale up company for the global biopharma sector but pharma and biopharma sector but based here in Dublin. Jacobs which is an international consultancy firm but their Dublin office who is our main partner has specific expertise in pharma and biopharma projects and the ICME which is the international accreditation body for the chemical engineering profession to which all of our chemical engineering programs subscribe. Here we've had one new member Dr Melissa Hoare who is the training manager with Nybert based here in Dublin. Six months ago what did we say we were going to do? We said we were going to develop a series of learning suites focusing on very specific areas, fermentation, chromatography, distillation and process modelling control. All very broad topics but we're looking specifically at pharma and biopharma applications. We're again developing these resources to support a theory experiment experimentation simulation scaffold or around that scaffold. These reusable resources will ultimately be available to students in all relevant disciplines through an open online platform. And we are focusing on a curfewly selected limited set of industry relevant and very widely used commercially available simulation and modelling tools listed here. What have we done? Our project started on March 1st rather than on January 1st because the timing of the project was designed to ensure that students could be involved in resource development and in resource evaluation. And also to allow us to meet the not insignificant recruitment challenges associated with finding appropriate candidates for the positions. We had an inception workshop in Nybert, generously hosted by Nybert, one of our partners in March of this year. There we had working package overviews, clarification of our learning outcomes and preliminary identification of our learning resources. And because this is really done at the interface of the chemical engineering, the subject experts and the educational technology experts, this was a really important outcome from that workshop. Our work is subdivided into work packages, work package to deal specifically with multimedia resource development. And I'm delighted to ask Dara Coatley from CIT who co-leads this package with Dr Garoda Sulawain to summarise their activity in this area to date. Dara, thank you. Thank you. So a number of questions arose with regard to multimedia development at the proposal stage and in the initial meeting. And these questions primarily related to the need to develop a number of different multimedia resources across a number of different work packages dealing in quite specific kind of content areas. So questions included how many resources to be developed, the level of media richness that could be achieved against time and budget, interactivity, pedagogical effectiveness, so is this piece of content best served by a screencast, by an interactive simulation, by a number of pages of text-based content, and also issues related to granularity and consistency. And those last two elements I think kind of really represented a fear that, done incorrectly, the development of multimedia resources would become several small sub-projects across a different work packages as opposed to a more unified whole. And that, when it came to put these together, that resources from one work package would not communicate very well with resources from another. So the solution which we have decided upon as a way of addressing all these concerns is based on the development of small self-contained and granular learning objects with multimedia resources at the heart of these and based around the spiral learning approach of theory experimentation and simulation, which was mentioned by Patricia earlier. So the intention is that, in this way, small learning objects would be able to put together to form larger courses, would be easily distributed to additional OERs, and also could be downloaded and used individually by individual lecturers to support their own teaching practice. So multimedia development is ongoing at the moment. We've adopted an approach based on the success of approximation model. So this process involves an initial stage of visualization, data gathering, and collaboration. A representation is given here of a visualization of the curriculum for work package six, distillation broken down into different subject areas, learning outcomes, and then desired multimedia resources based on these. Content is then added by subject matter experts into appropriate templates in order to best structure it from an instructional design point of view for the appropriate resource, be it a simulation, a video demonstration, a screencast and so forth. For each of these resources, a number of pre-production media screens are developed. An example is given here of storyboards for a screencast for distillation. And all of this is decided upon and signed off by all the relevant stakeholders before production begins. And the intention here really is to just maximize efficiency, to minimize any potential issues which could hold up time and use of resources. So as I mentioned, this process is ongoing at the moment. It's ongoing specifically with work package six, distillation. And the intention with essentially focusing on one work package before moving on to additional work packages is the intention that by going through the process once appropriate tweaks if necessary can be made to processes, to templates, one and so forth. And that this thing can be easily rolled out with the other work packages in order to again just maximize efficiency and to reduce any unnecessary waste of time and resources. So moving on to give what will to the frustration of the work package leaders here, be it just a whirlwind summary of what they have done or what we have done in each of the remaining four subject area work packages. Chromatography, a very important, extremely expensive downstream processing and purification operation in the biopharmaceutical industry is led by Dr. Carmel Hensey from UCD. The experimental systems are provided, experimental pilot scale systems are provided by Nybert. Working together with Nybert and the chemical engineers, Carmel and her team have defined the chromatographic process. They have broken it down into a series of discrete steps, which will each be tackled individually in terms of learning resources. They've recruited an MSC project student who started work at the beginning of the month and we've been given six weeks in Nybert of access to their pilot scale facilities, which is going to start on June the 20th. In terms of fermentation, which is really I suppose the heart of most of bioprocesses, this work package is led by Dublin City University, the School of Biotechnology, specifically it's led by Dr. Brian Freeland. The specifications are complete, the experimental, the experimental design has been defined. Personnel has been recruited to the project, included an additional unanticipated master's project student from Freiburg and the students have been trained in the operation of the pilot scale fermentation system. This is a very experimentally heavy element of the work package, basically the accumulation of experimental fermentation data, which will then go on to seed the modeling and simulations. There's an off gas analyzer, which is a luxury, not usually available to undergraduate students on fermentation systems, it's funded by the project. And it's going to yield a richer, more modeling and simulation amenable data set, and that's already been ordered but not yet invoiced. One additional unanticipated part of this project was we'd originally thought that most of the simulation would be done in a lab view environment. However, as a result of interaction with scale up systems who produce DynaChem, we now anticipate a much larger role for DynaChem modeling exercises associated with this fermentation element of the project, and I think that's going to be particularly useful. This slide just illustrates schematically how all of these elements will come together, showing in the center the use of the Nibert industry standard pilot scale fermentation systems to which our students in any of the institutions would not normally have access and which will be specifically employed in the tutorial videos. Process control is another interdisciplinary area. It's grounded in electrical engineering, but all of the applications are discipline specific or sector specific. It's led by DIT by Dr. Dave Doran. They have identified target processes here, which will be the focus of this work package, which are of broad applicability to pharma and biopharma applications. You'll see distillation, for example, in there, which is going to come in in the next work package. They've recruited the postgraduate researcher who's funded by this program. He'll start work on the 20th of this month, and there are three summer interns who have already started work here. What we're not trying to do with this is to reinvent the wheel. So quite a lot of this work package's effort today has gone on finding out exactly what good resources are out there already, what formats are, find, echo well or resonate well with students, and this is the example of the type of graphical user interface which is anticipated for this work package. Distillation is led at UCD by my colleague Dr. Damian Mooney, and distillation, while it's of use by chemical engineers in almost all sector, within the pharma and biopharma industry applications are mainly confined to solvent recovery and solvent swap. We've recruited the personnel. Three final year project students have been working on this during the past semester. Four summer interns have started, well three have already started, one is starting this week, and we've just recruited the MNJC student who will start on the 1st of July. We have laboratory to pilot scale, simple batch to batch with reflux systems at various stages of development, redevelopment and validation, including a system which has been donated by APC and for which technical support has been provided by APC. The simulation element of this work package is particularly rich because it's going to include, it will span, simple systems, simple batch distillation systems to complex multi-component, multi-column systems. It's going to allow the students to develop a variety of skills in the use of graphically based systems, flow sheeting systems and coding systems. And here again, unanticipated additional input from our industrial partners. For the national impact, I think the potential for national impact is immediately obvious here in the direct involvement of every chemical engineering programme in the country. Students from selected institutions are already involved in the development of the resources. Students from all institutions will be involved in the testing and the re-evaluation and ultimately in the use of these resources. We've been drawing a higher than anticipated profile through our external partners and in July, every chemical engineering intern from each of the institutions and their employers will all be asked to participate in a survey on the use of the simulation tools. Evaluation and sustainability have been built into the project from the very beginning. We're really too early into the project to be deeply engrossed in the evaluation. But I think the key element of this is, this is really important, the chemical engineering profession. It's important to chemical engineering educators around the country. We're committed to embedding these resources and the learning outcomes in the accreditation, in our professional accredited curriculum, which are absolutely central to the recognition of our graduates as they emerge from our programmes. Thank you very much.