 Background Anacetylcysteine, NAC, is a mucolytic agents with anti-inflammatory properties that has been suggested as an adjunctive therapy in patients with COVID-19 pneumonia. Objectives We conducted a systematic review and meta-analysis to evaluate available evidence on the possible beneficial effects of NAC on SARS-CoV-2 infection. This article was authored by Periskeva Stemistoclas, Cantani's Anastasios, Carolus Iasif, and others.