 We mutate it and we'll try to screen it and see if any of the mutants from this molecule can sense voltage inside themselves Library was up to 10 millions up 10 millions individual clones Screening of each cell Manually take several so minutes So it means I wouldn't be able to finish probably this screen of this library till nowadays if I start doing it manually and Was saying oh, how about we just make robot to do it for us? and This is how we end up with designing a special robot that can Image very large population of the cells Automatically pick the best cells expressing the voltage sensing molecule And select using a micropiped and everything in the in automated mode in fully automated mode I remember with this day when I click start it took me about two years to make it to happen But once it's everything was set we click start bottom Robot did it for us for two hours while I was drinking coffee at Vendor this process. I take the tube With a few cells selected from the plate I clone the genes and one of them was the Archon voltage sensor that we currently using for voltage imaging in vivo