 The study evaluates the antifungal activity of selenium nanoparticles, CNPs, synthesized using Iranian cyanobacterial strain desmonostoc albarizicum, and shows that CNPs have a hexagonal structure with an average crystal size of 58.8 nanometers and a zeta potential of plus 22.7. The study also reveals that pithium ultimum is the most resistant fungus to CNPs while alternaria alternata is the most sensitive. The results suggest that CNPs synthesized by Iranian cyanobacteria could be effective candidates in medical applications. This article was authored by Bahenaruzi, Bilal Saad Jaleel and James S. Metcalfe.