 This paper reviews the potential of combining hypothermia-mediated photothermal therapy, PTT, and reactive oxygen species, ROAS, mediated photodynamic therapy, PDT, to treat multidrug-resistant MDR bacteria. It explains how the two techniques work together to create a more effective treatment than either one alone. The paper also discusses the mechanisms behind the synergy between the two techniques and introduces advances in nanotechnology-based PTT and PDT agents. Finally, it outlines the challenges and future perspectives of this approach. This article was authored by Atenu Naskar and Kwon Sun Kim.