 This paper presents a comprehensive methodology for evaluating the economic impact of earthquakes on transportation networks. It combines geographic information systems, GIS, probabilistic seismic risk analysis, and traffic simulation models to estimate the direct and indirect costs associated with damage to bridges and increased travel times. Additionally, it considers the social cost of reduced accessibility caused by disrupted transportation routes. This framework was tested on a realistic bridge stock in central Italy, where detailed land use data were collected and a traffic model was calibrated. Finally, a shake map derived from a historical real seismic event was used to perform a probabilistic risk analysis. This article was authored by Alessandro Rasulo, Sofia Nardojeni, Azza Evangelisti, and others.