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Physiology of Gastric acid secretion: Mechansim, Regulation and Phases

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Published on Jul 16, 2011

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This animation by Medchrome gives you a clear idea about the mechansim of secretion of gastric acid from parietal or oxyntic cells of stomach, its regulation (stimulation and inhibition) and various phases of gastric acid secretion.

Parietal or Oxyntic Cells are situated mainly towards neck of glands and secrete hydrochloric acid (HCl) and intrinsic factor. The cells have an extensive microcanlicular system which communicates with the lumen of the gland by a canaliculus. In resting stage of cell, part of the microcanalicular system is converted into the tubulovesicular structures (vesicles are fused with the microcanalicular system when cell is stimulated to secrete HCl).

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