 Silver nanoparticles, AGNPs, have been studied as potential antimicrobial agents due to their ability to kill multidrug-resistant MDR pathogens. These particles can cause cellular death through multiple mechanisms, including disrupting the outer membrane, enzyme activity, DNA, and protein structures. This synergistic effect makes them more effective than traditional antibiotics. The effectiveness of AGNPs depends on their size, shape, and surface modifications, which can be tailored to optimize their antimicrobial activity. This article was authored by Ariana Menischetti, Alexander Mavridi-Prentisi, Dario Mordini, and others.