 In Alzheimer's disease, AD, microglia, brain-resident immune cells become chronically inflammatory and neurotoxic. Recent research has focused on neuroinflammation as a potential cause for AD and cognitive decline. Genetic variants of certain molecules, such as TRM2, are linked to increase risk of developing AD and cognitive decline. Extra virgin olive oil, EVO, polyphenols, olurapenoglycone, olea, and hydroxatyrosol, HT, have been shown to reduce inflammation and improve cognition. These compounds reduced levels of pro-inflammatory cytokines, activated the TRM2-dependent anti-inflammatory pathway, and promoted protective microglial activity favoring the M2 polarization phenotype. This study provides insight into how EVO polyphenols can be used to combat neuroinflammation and cognitive decline. This article was authored by Manuela Lurie, Marzia Vasari, Federica Carnamala, and others. We are article.tv, links in the description below.