 The study investigated the role of SYK-coupled C-type lectin-member 2, CLE-C2, in the pathogenesis of SARS-CoV-2-induced thrombo-inflammation. The researchers found that CLE-C2 interacted with the receptor-binding domain, RBD, of SARS-CoV-2 spike protein, SARS-CoV-2-RBD. This interaction led to the activation of platelets, resulting in the production of neutrophil extracellular traps, nets. In addition, administration of CLE-C2.fc, a monoclonal antibody against CLE-C2, inhibited SARS-CoV-2-induced net formation and thrombo inflammation in AAV, ACE2-infected mice. These results suggest that CLE-C2 is a novel pattern recognition receptor for SARS-CoV-2, and CLE-C2.fc could be used as a potential therapeutic agent to reduce the rest of post-acute sequelae of COVID-19, PASC. This article was authored by Pei Shan Sun, Cheng Piyu Sun, Am I Who A Tao, and Others? We are article.tv, links in the description below.