 This study found that genetic predispositions to smoking and alcohol consumption were associated with an increased risk of several gastrointestinal diseases. Smoking was linked to 20 different types of gastrointestinal diseases, while alcohol consumption was linked to only four. Additionally, genetic predispositions to smoking were also associated with an increased risk of some gastrointestinal diseases even when adjusted for genetic predispositions to alcohol consumption. This article was authored by Shuai Yuan, Jia Chen, Shixian Yuan, and others.