 Hello everyone, my name is Dr. Shubham Naneshwajatap. I am JRDU, Department of Radio Diagnosis in Dr. Vasantrapur Medical College and Research Center, Nasik. My topic today for our paper presentation is MR Imaging Appearance of Lisen Kefeli, abstract. MR imaging of a patient with epilepsy and psychomotor retardation at a six-year-old revealed diffuse pathchick area on MR imaging. The change of the MR imaging findings may have resulted from myelination in the intracortical and sub-cortical fibers. It is important for clinicians to be aware of longitudinal changes of cerebral cortex in Lisen Kefeli. Introduction. Lisen Kefeli is a basket term for a number of congenital cortical mark formation characterized by absent or minimal salcation. Lisen Kefeli is a mark formation of a cortical development characterized by a smooth cortical surface, the term encompasses a spectrum of a chiral mark formation caused by mutation of a number of different genes ranging from a completely chiral, that is absent chiral, to patchy chiral, broad chiral, and is always associated with an abnormally thick cortex. Imaging studies of a patient with a Lisen Kefeli reveal a smooth brain surface or a pattern of broad chiral with a thickened cortex and a smooth cortical white matter junction. Lisen Kefeli's pecky area can be further divided into type one classic and type two cobblestone. They differ in a clinical presentation underlying genetic abnormalities as well as microscopic and microscopic, including imaging appearances. Case report. A six-year-old female child was born at the 38th week gestation without complication as a first child of healthy unrelated parents. Family history was unremarkable, presented with a global developmental detail and history recurrent episodes of conversion. Neurological examination was unremarkable except for hypokinia. Facial appearance, cranial nerves, and deep tendon reflexes were not. On MRI imaging, there is a thick band of abnormal T1 hyperintense, T2 hyperintense signal intensity deep to the cerebral cortex. It parallels the cortex in a contiude and signal intensity, such as to a band heterotopia. There is also a thick, diminished, over-lying gyra with shallow sulcan seen such as to a pecky area, mild prominence of lateral and third ventricle C. Corpus callus appears normal. So, as we can see, this is T1-mated axial image and T2 T1-mated surgical image. Corpus callus appears normal. So, this is T2-mated axial image and T2-mated another T2-mated axial image. There is also a thick band of abnormal T1 hyperintense and T2 hyperintense signal deep to the cortex. Thick and diminished over-lying gyra with a shallow sulcan seen. Mycerminus of lateral ventricle seen. This is diagrammatic refrigeration of surgical cortex in a four-layer pecky area. In normal brain, in this way, layer one, two, three, and four are arranged in normal brain. In pecky area, this is a discussion. The term lisentkivalli is derived from the three for smooth lissos and brain in kefellos. Lisentkivalli, liss which involves agaerea and pecky area. With subcortical band hetropoeia encompasses a spectrum of malcarbation of cortical development caused by insufficient neuronal migration. In severe lisentkivalli, the cortex lacks surface folds agaerea while milder manifestations include abnormally broad folds pecky area. Although lisentkivalli can be identified on all cross-sectional modalities, antinatal, neuronatal, ultrasound CTNMR, MR is a modality of choice to fully characterize the abnormalities. Neuroblast are generated through the mitosis of neuronal stem cells in the ventricular zone of fetal brain between five and 22 weeks of gestation. Post-mitotic neuroblast undergoes radial migration output from the ventricular zone guided by the radial glalfibers to populate the subcortical blade. Embryonic cerebral cortex. Slow or arrestant migration lead to thicken cortex with reduced for all the standard neurons of a subcortical band hetropoeia. Pathologic evaluation of lisentkivalli has shown classic four-layer cortices with predominance of L1S1 mutations. In the classic four-layer pattern, two most superficial layers, molecular layer and the outer cellular layer comprise the outer remover of gray matter. Gross pathology imaging are formed by neurons that migrated normally early in gestation. Third layer, cell sparse layer consists of mainly axons and few neurons. The thick fourth layer is composed of many desolation neurons, whose migration appear to have been disrupted. As we have seen in this schematic, thick fourth layer. MRI remains the key investigation in assessment of lisentkivalli, lisentkivalli patient. LIS is a typically divided into typonic or classic type two or cobblestone complex which differ in a clinical presentation, genetic and imaging appearances. MR is a based imaging modality to allow accurate classification of this migration disorder. In the evaluation of these children with pecking area and other associated migration disorder, T1-weighted images will suffice, but all three projection exen-coronal subjectors are usually necessary to adequately evaluate this disorder. Anatomical detail including gray matter is extremely measured with MR. These are my references. Thank you.