 Since the start of the pandemic, numerous attempts have been made to develop idiotropic therapies for a novel coronavirus infection. Drugs such as hydroxychloroquine, lopinavir slash ritonavir, and derivatives of these compounds have been used as antiviral agents, but they have shown limited effectiveness and insufficient safety. Other groups of drugs with a more efficient and safe pharmacological profile are currently being actively used. The goal of this study was to analyze the literature references on the efficacy and safety of antiviral drugs for the treatment of COVID-19. Materials and methods, abstract databases such as PubMed, Google Scholar, and eLibrary were searched for articles published between January 2020 and September 2022. Key queries included COVID-19, idiotropic therapy, immunological drugs, antiviral drugs, interferons, and recombinant interferons. Results, several groups of drugs have been found to be of interest from the perspective of idiotropic therapy, including immunological drugs. This article was authored by D. N. Zemskov, L. A. Balakova, O. A. Radiva, and others. We are article.tv, links in the description below.