 This study aims to assess factors associated with COVID-19 vaccine hesitancy in Portugal using data from a community-based survey, COVID-19 barometer, social opinion, conducted from September 2020 to January 2021. The study found that COVID-19 vaccine hesitancy in Portugal was high, with 56% of respondents waiting and 9% refusing to take the vaccine. Several factors were associated with both refusal and delay, including being younger, loss of income during the pandemic, no intention of taking the flu vaccine, low confidence in the COVID-19 vaccine and health service response, worse perception of government measures, inconsistent and contradictory information, and answering the questionnaire before the release of safety and efficacy information about the vaccine. The study highlights the importance of building confidence in the COVID-19 vaccine through effective communication and increased trust. This article was authored by Patricia Soares, Joao Victorosha, Marta Moniz and others. We are article.tv, links in the description below.