 Poly, Epsilon-Caprolactone, S, PCLs are biodegradable and biocompatible polyesters with great potential for use in drug delivery applications. PCLs can be modified by ring-opening polymerization, ROP, of functionalized Caprolactone monitors to incorporate various functionalities such as hydrophilic or hydrophobic groups, enabling them to respond to external stimuli and target specific locations. These properties make PCLs attractive candidates for drug delivery applications. This review summarizes recent developments in PCL-based drug delivery systems, including their morphological characteristics, drug loading and release capabilities, and targeted delivery. This article was authored by Ubi Badrin, Tejas Shah, Godwin K. Babinaina, and others.