 The promise of science is to chart unknown domains of knowledge and develop understanding of how the world works. When science is working well, it improves health and eliminates disease, enhances education, addresses poverty and conflict. It's a means for innovation. But when it isn't working, it can disguise bad research, generate false hope, or just be hugely inefficient. The Center for Open Science mission is to increase openness, integrity, and reproducibility of scientific research. Reproducibility is central to science because we're not supposed to trust a scientist based on authority. We're supposed to be able to recreate their evidence and their findings in order to be able to trust the evidence itself rather than just the argument. Right now, a scientist's primary incentive is to publish, and publish as frequently as possible. The Center for Open Science creates free software to support the research workflow and make it easier to share research materials and data. We're building a community, and we're also creating standards on open research practices. We also work with the stakeholders in science to change the incentives that motivate scientists' behavior. With your support, the Center for Open Science will improve the alignment between scientists' daily practices and their scientific values, so that we can meet many of the world's challenges with good evidence for solutions. Thank you.