 Graphene has unique physical and chemical properties, which make it ideal for use in sensor technologies. Researchers have developed various biosensors using graphene and its derivatives as scaffolds to detect and identify a wide range of diseases, pathogens, and biomolecules linked to disease. Antibodies, DNA, and enzymes have all been attached to graphene surfaces through covalent bonding or physics option, and then used in electrochemical detection methods. This review summarizes the current state of research into graphene based biosensors and their potential applications in life science and medicine. This article was authored by Janaya Pina Bahamund, Hangen Nguyen, Sophia K. Fanarakis, and others.