 Highly pathogenic avian influenza, HPAI, A H5N1 viruses from lineage 2.3.4.4 B are rapidly invading the Americas, causing massive die-offs in marine mammals and seabirds, including dolphins, sea lions, sandalings, pelicans, and cormorants. The Peruvian viruses are for colon for reassortance with genomic segments from both Eurasian and American lineages, rapidly accumulating mutations of concern that warrant further examination and highlight the urgent need for active local surveillance to manage outbreaks and limit spillover into other species, including humans. This article was authored by Mariana LaGuaia, Alejandra Garcia-Glesna, Brino Muñoz-Sovetra, and others.