 mesenchymal stem cell, MSC, transplantation has been explored as a new clinical approach to repair injured tissue. With studies highlighting two important aspects, MSCs can modulate T cell mediated immunological responses and systemically administered MSCs home to sites of ischemia or injury. The mechanisms of immunomodulation involve low immunogenicity, antigen presentation capabilities, paracrine interactions with dendritic cells and T lymphocytes, and prostaglandin E2, endolaming 2, 3-dioxygenase, and toll-like receptor signaling pathways. The homing of MSCs involves activation, rolling slash adhesion, and transmigration into target tissues during inflammatory or ischemic conditions. These aspects are contextualized to understand a reported side effect of MSC therapy, cancer development. This article was authored by Hiroshi Yagi, Alejandro Soto Gutierrez, Biju Perekadan, and others. We are article.tv, links in the description below.