 This systematic review assesses the effects of various interventions on monogenic insulin resistance, IR, stratified by genetic etiology. The study includes 10 non-randomized experimental studies, 8K series, and 23 case reports. Metaleptin is associated with lowering of triglycerides and HbA1c in all lipodystrophy, partial, and generalized lipodystrophy, as well as in specific genetic subgroups. Thiasolidindians are associated with improved HbA1c and triglycerides in all lipodystrophy, improved HbA1c in PARG, and improved triglycerides in LMNA. IgF1 is associated with improved HbA1c in INS-related IR. However, the small size or absence of other genotype treatment combinations precludes firm conclusions, and there is insufficient evidence to assess efficacy and risks in aggregated lipodystrophy or genetic subgroups for other interventions. This article was authored by Robert K. Semple, Kashyapay Patel, Sun Young-O, and others. We are article.tv, links in the description below.