 Vaccine hesitancy is a major barrier to population-wide protection against COVID-19. In this study, we found that black African Americans, individuals with lower educational attainment and those with low levels of trust in vaccines were more likely to report hesitancy to take the COVID-19 vaccine. These findings highlight the need for targeted interventions to address vaccine hesitancy and reduce health disparities during the pandemic. This article was authored by Donnie Willis, Jennifer A. Anderson, Kenesha Bryant Moore, and others.