 Aptomers are short strands of nucleotide sequences that combine to target molecules with high affinity and specificity. They are being used in the development of novel and portable point of care, POC, diagnostics, which are essential for resource-limited settings. Aptomers offer several advantages over traditional antibody-based recognition elements, such as smaller size, lower immunogenicity, and faster generation times. Additionally, computational tools can be used to predict the reliability and functionality of apt-amor models, enabling the optimization of POC device designs. This article was authored by Yusuf Aslan, Mariam Atabey, Hussein Khasar Choudhury, and others.