 This study explores the preferences of adolescent boys and young men for pre-exposure prophylaxis, PrEP, uptake in South Africa, Uganda and Zimbabwe. The results show that 65.22% of participants preferred on-demand PrEP, with factors such as country and advanced planning of sex being independently associated with this preference. Qualitative data supports the preference for on-demand PrEP in those who plan sex in advance. HIV intervention programs should offer both on-demand and daily PrEP to engage more adolescent boys and young men in HIV prevention practices. This article was authored by Ayub Kokonda, Andrews and Tugosimita, Richard Mohomuzza, and others.