 CryoEM has revolutionized the way we do structural work and how we understand what molecules look like in three dimensions. The limits of the technology in cryo-electron microscopy are a lot at the front and back end, meaning sample preparation and also data analysis and data mining in general. Going forward, I think the ability to look at time-resolved processes and getting more different types of structures is where we're headed. So I think technical is doing everything right. I'm very, very impressed. All of that is exactly spot on right and I think you've done a beautiful job in going in exactly the right direction.