 Bacterial cellulose, BC, is the type of cellulose produced by certain types of bacteria when grown under suitable conditions. It is characterized by its unique three-dimensional structure, which consists of a dense network of nanoscale fibers. This structure makes it ideal for use in various applications, including paper production, electronics, and tissue engineering. BC nanocomposites are composed of BC and other materials, such as polymers, metals, ceramics, and biomaterials. They can be fabricated using static or agitated methods, depending on the desired end product. Biocompatibility testing is important for developing BC-based materials for medical applications, such as bone, skin, and cardiovascular tissue engineering. This article was authored by Omar Petroncoso, Solene Kamos, and Fernando G. Torres.