 This study investigates the role of neuropeptide Y, NPY, in migraine-like phenotypes. It uses a mouse model of migraine induced by glyceryl trinitrate, GTN, and finds that GTN reduces the number of GFP plus cells in the medial herbenula, MHB. The authors also show that NPY can reduce GTN-induced allodynia and anxiety, suggesting that NPY signaling in the MHB plays a role in the modulation of migraine-related symptoms. Additionally, they demonstrate that activation of the Y1 receptor tenuates GTN-induced allodynia and anxiety, providing evidence that the Y1 receptor could be a potential target for treating migraine. This article was authored by Chen Xiaoyang, Zihua Gong, Xiaocheng Zhong, and others.