 This study explored the perception of nurses on the use of mobile phone SMS for managing diabetes in rural Ghana. Nurses believed that SMS was beneficial in facilitating communication with patients, their families and other stakeholders, as well as improving medication adherence and supporting blood glucose monitoring. They also found it easier to communicate with digitally literate patients via infographics than through traditional SMS. However, they lacked knowledge about downloadable diabetic applications. Despite this, nurses were generally positive towards the use of SMS for diabetes management.