 Let's TalkShots is a personalized vaccine risk communication website designed to address patient-level education on vaccinations. The website uses a variety of methods including animated videos, credible sources, and personal narratives to provide accurate and reliable information about vaccines. The website has been successfully tested in English, Spanish, and French, Canadian, and has shown positive results in terms of engagement and understanding of vaccine risks. This article was authored by Daniel A. Salmon, Daniel A. Salmon, Daniel A. Salmon, and others.