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Simulating seizure onset location and progression for temporal lobe epilepsy

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Published on Dec 10, 2015

The animation shows a simulation of how epileptic seizures start and propagate in a 44-year old female patient with left temporal lobe epilepsy. Simulations are based on how strongly the 82 different regions of her brain are connected. Such structural connectivity information is available through Magnetic Resonance Imaging (MRI) measurements that use diffusion tensor imaging.

Here, we show the recording from 8 regions that we found were involved in seizures for this patient. High-amplitude epileptic activity starts in one region (upper left channel) with later activations of other regions. The spatial locations of regions are indicated on the left side viewing the brain from the top (horizontal plane).

This model is a first step in identifying regions that are involved in epilepsy for individual patients in order to identify targets for neurosurgery or brain stimulation.

For more information, check out the research article at:
http://journals.plos.org/ploscompbiol...

Computational modelling for brain stimulation is related to
http://www.cando.ac.uk/

Support our research at https://www.patreon.com/marcuskaiser

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