 Boron Neutron Capture Therapy, BNCT, is a type of radiotherapy that induces cell damage through a localized nuclear reaction. Here the authors describe the design of a carburene-based covalent organic framework as a boron capsule loaded with immune adjuvants for concurrent BNCT and immunotherapy, promoting antitumor immune responses in preclinical cancer models. This article was authored by Yashincha, Chibinkwa, Chongfu, and others.