 Transnasal Humidified Rapid Insufflation Ventilatory Exchange, Thrive, is a technique used to improve oxygenation and reduce carbon dioxide levels when self-respiration is maintained. However, its use has been limited in certain situations, such as epistaxis or basal skull fractures. A case study was conducted on a morbidly obese patient with subglottic stenosis who was successfully treated using Thrive, via the oral route while under general anesthesia and spontaneously breathing. This technique may prove to be an effective alternative for patients with similar conditions. Further research is required to confirm this finding.