 WNT-Caitlin Signalling plays a crucial role in the development and progression of several types of cancers. Targeted therapies aimed at disrupting this pathway are being explored as a way to treat these diseases. Despite some successes, there remain significant challenges and limitations associated with these approaches. This review provides an overview of the current state of research on WNT-Caitlin Signalling in cancer and its potential applications in targeted therapy. This article was authored by Fanyuan Yu, Chonghao Yu, Fei Fei Li and others.