 The study examined the solubility of Hesperidin, HES, in various aqueous deputectic solvents, deses, at different temperatures. The solubilities of HES in these deses were determined using Vanthoff, Jouabanakri, and modified Apelblatt-Jouabanakri equations. Additionally, the Hanssen solubility parameter was calculated to analyze the dissolution process of HES in the four aqueous deses. This article was authored by Hamayat Shikari, Mohammed Targi Zafarana Mota, Masoomah Maktapa, and others.