 This study examines the effects of proprioceptive neuromuscular facilitation, PNF, and resistance training on exercise-induced hypoalgesia, EIH, and conditioned pain modulation, CPM, among patients with myofacial pain syndrome. The results suggest that PNF, isotonic, and isometric exercises can lead to local and global EIH effects, and the improvement in CPM response following PNF and isotonic exercises may be attributed to the enhancement of endogenous pain modulation via motor sensory interaction from additional eccentric and dynamic muscle contraction. This article was authored by Zihan Su, Nanen, and Ziru Wang.