 Glutamine is essential for the growth and survival of cancer cells. It is used by cancer cells to produce energy and build proteins, and it also provides them with nitrogen for building amino acids and nucleic acids. Research has shown that targeting glutamine metabolism could be an effective way to treat cancer. This review summarizes the current understanding of how glutamine is metabolized in cancer cells, and outlines potential strategies for targeting glutamine metabolism for cancer therapy. This article was authored by Jong-Woo Jin, Jung-Kyu Byung, Jung-Kyung Choi, and others.