 The study examined the impact of a single nucleotide polymorphism, S&P, in the bovine CMH gene, which encodes an enzyme responsible for converting new 5GC into new 5AC. The S&P, C.1271C greater than T, P424L, was found to be associated with increased risk of disease due to its potential to disrupt the structure and function of the enzyme. Furthermore, the mutated form of the enzyme was predicted to be more stable than the wild type, suggesting that this S&P may have a direct effect on the pathogenicity of the bovine CMH gene. This article was authored by Aluamea Joshua Ogan, opiomy S. S. Sormykin, George Thaler, and others.