 TRPV4 is a polymodal, calcium permeable cation channel that is involved in several diseases. It has been shown to be activated by gain-of-function mutations, which causes hereditary neuromuscular disease. In addition, it interacts with ROA, a small GTPase, which regulates its activity. By studying the structure of TRPV4 in complex with ROA, researchers have discovered how the two proteins interact, and how this interaction affects TRPV4's activity. This knowledge could potentially be used to develop new treatments for TRPV4-related diseases. This article was authored by Duhun Kwon, Fengjong, Brett A. McCray, and others.