 The E4B program is a comprehensive training program designed to equip biomedical researchers with the necessary skills to succeed in today's rapidly changing environment. This program provides trainees with the tools needed to identify and validate opportunities for innovation, sell their innovations to diverse audiences, assess the ethical implications of their work, work in teams, and develop resiliency as an innovator. Additionally, the program includes mentor support, a team-based capstone project, and an optional in-person boot camp. The program has been well received by trainees who have reported increased knowledge and ability to perform tasks taught throughout the program. This article was authored by Jane M. Garbutt, Joseph Grayler, Lily Levin, and others.