 This study compared the ability of four vaccines to protect against SARS-CoV-2 variants of concern, alpha, beta, gamma, delta, and omicron. The study found that mRNA-1273 vaccine had the best protection against these variants, followed by BNT-162B2, AZD-1222, and ADD-26.CoV-2.S. Additionally, the study showed that the mRNA vaccines were more effective than the adenovirus-vector-based vaccines, at neutralizing the omicron variant. This suggests that mRNA vaccines are better suited for initial and booster vaccinations against SARS-CoV-2 variants. This article was authored by Mar J. Vangills, Aishela Vel, Karlyn Benderstratton, and others.