 Oxidative stress and ferriptosis are two major factors involved in the development of Alzheimer's disease, AD. A recent study has shown that O-R-M-D-L3, a mitochondrial antioxidant, plays a key role in the progression of AD by promoting oxidative stress and ferriptosis. This study suggests that O-R-M-D-L3 could be a potential therapeutic target for AD. This article was authored by Yang Kun Shao, Yilin Xu, Hwang Di-Ai, and others.