 This study examined the hesitancy towards a future COVID-19 vaccine among parents in a major metropolitan area. It found that parents of certain demographics are more likely to be hesitant towards a future vaccine, such as non-Hispanic black parents, parents of publicly insured children, and lower-income families. Additionally, parents who obtained information about COVID-19 from family members, the internet, or healthcare professionals were less likely to be hesitant towards a future vaccine. This suggests that targeted outreach efforts should be made to these groups in order to ensure equitable uptake of a future vaccine. This article was authored by Nina L. Alfiei, Jennifer DeCousma, Nia Herb-Garris, and others.