 Topology optimization is a key aspect of structural design in metal additive manufacturing, which has gained immense attention in various industries such as aerospace, medical, automotive, and others. The review focuses on the utilization of topology optimization for structural design in metal additive manufacturing, discussing its symbiotic relationship with the technology, support structure design, limitations, emerging efforts to adopt artificial intelligence models, and open-source and commercial software capabilities. This article was authored by Acesua Ipadoid, Jidong Jong, Jeffrey Sixt, and others.