 Indocialin is a protein expressed by hepatic stellate cells, HSCs, that plays a key role in regulating the balance of liver regeneration and fibrosis. In this study, researchers found that HSC-expressed Indocialin was negatively correlated with tumor cell proliferation in human hepatocellular carcinomas, HCCS. Furthermore, when Indocialin was genetically inactivated in mice, it led to faster tumor growth. The researchers also discovered that Indocialin negatively regulates the expression of certain proteins involved in liver cancer development, such as insulin-like growth factor 2, IGF2, retinol binding protein 4, RBP4, DICOF1, DKK1, and chemikine ligand 5, CCL5. These findings suggest that Indocialin may be a potential therapeutic target for treating liver cancer. This article was authored by Caroline Mogler, Kourtney Koenig, Matthias Wieland, and others.