 Timely and reliable animal disease reporting is more important than ever before, especially when it comes to emerging zoonotic diseases that may pass from animals to humans and cause epidemics or even pandemics. Early warning and quick response to high-impact animal diseases which can cross boundaries is essential for global health security. Originally launched in 2004, MPRESI is an integrated web-based application designed to support veterinary services by facilitating the sharing of national, regional and global animal disease information. By using MPRESI, countries around the world can share information securely, support prevention, improve risk management and coordinate the approach to reduce the impact of current and future outbreaks. MPRESI also shares this information with its partners and stakeholder networks. Data is shared through MPRESI directly to the Global Early Warning System for major animal diseases, GLUS+, which is run jointly by FAO, the World Organization for Animal Health, OIE and the World Health Organization, WHO. This supports the coordination of risk assessments of zoonotic threats, data sharing and initiation of public health responses. Most importantly, by sourcing information from around the world, MPRESI consolidates both official and unofficial disease events to create a verifiable, reliable and interactive platform that puts the right information in the hands of the right people at the right time. MPRESI has successfully allowed users to track geo-referenced information, analyze events, collect and display information from different sources and, through the development of models and forecasting tools, it allows veterinary departments to focus their attention and surveillance efforts. Now, MPRESI has been updated to give greater functionality. The new MPRESI Plus includes improved features such as an innovative cloud-based platform that shares information with partners in the public health, animal health and environmental sectors, advanced analytics, interactive maps and visualization tools that provide information in real time, improved risk assessment, forecasting and early warning functions that effectively identify health threats, and improved data quality that facilitates evidence-based decision-making. MPRESI Plus Global Animal Disease Information System has a huge role to play in the identification and mitigation of transboundary high-impact animal disease threats. Through collaboration and sharing, we can reduce the threat to livestock production, food security, public health and the economy.