 The PI3K-AKT-MTOR signaling pathway is a complex network of proteins involved in various cellular processes including cell growth, differentiation, and survival. It has been implicated in numerous diseases including ischemic brain injury, neurodegenerative disorders, and cancer. Several drugs targeting this pathway have shown promise in preclinical trials and some have been tested in humans for treating certain types of cancers and neurological conditions. This article was authored by Faishu, ListenNA, Yemfei Li, and others.