 This study examined the role of long non-coding RNA01534, LINK01534 in colorectal cancer, CRC. It was found that silencing LINK01534 suppressed cell proliferation, invasiveness, and cell cycle progression at the G2M phase and promoted apoptosis. Additionally, it was discovered that silencing LINK01534 suppressed cancer stemness while it activated the ER stress response, especially through the PERC slash EIF2 alpha signaling pathway. Furthermore, LINK01534 was found to be expressed in tumor cells and upregulated in CRC tissues compared to normal epithelium. A survival survey indicated that high LINK01534 expression was significantly associated with shorter overall survival in 187 CRC patients. These results suggest that LINK01534 may be an important modulator of the maintenance of cancer stemness and suppression of the ER stress response and that it could be a novel prognostic factor in CRC. This article was authored by Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, and others. We are article.tv, links in the description below.