 The study examined the genetics of South Asians, including those from Pakistan, India and Bangladesh. It found that there was a high rate of reproductive isolation, endogamy, and consanguinity among them, which led to higher levels of rare homozygosity than what is typically observed in outbred populations. This increased the power to identify genetic variants associated with diseases, making South Asia a unique location for population scale genetic studies. This article was authored by Jeffrey D. Wall, Jafar Saffra Ponsasuti, Ravi Gupta, and others.